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Research Overview
My primary research interests include examining the physiological and molecular effect of nutrition and exercise on the coagulation and fibrinolytic systems as well as understanding the mechanisms underlying stress induced stroke, MIs, and DVTs. Currently investigating health benefits of whey protein on antioxidant, inflammatory, vascular, and endocrine markers.
Education
Ph.D. University of Florida 2008 (Chemistry)
M.A. University of Scranton 2002 (Biochemistry)
B.S. University of Scranton 2000 (Medical Technology)
Featured Publications
Ballard, K.D., Bruno, R.S., Seip, R.L., Quann, E.E., Volk, B.M., Freidenreich, D.J., Kawiecki, D.M., Kupchak, B.R., Kraemer, W.J., FACSM, and Volek, J.S. “Acute ingestion of a novel whey-derived peptide improves vascular endothelial responses in healthy individuals: A randomized, placebo controlled trial”. Nutrition Journal. 2009, 8:34-41.
Kupchak, B.R., Garitaonandia, I., Villa, N.Y., Smith, J.L., Lyons, T.J. Antagonism of human adiponectin and their membrane progesterone receptor paralogs by TNF and a ceramidase inhibitor. Biochemistry. 2009, 48(24):5504-5506.
Garitaonandia, I., Smith, J.L., Kupchak, B.R., Lyons, T.J. “Adiponectin identified as an agonist for PAQR3/RKTG using a yeast-based assay system”. J. Recep. Signal Transd. 2009, 29(1):67-73.
Villa, N.Y., Kupchak, B.R., Garitaonandia, I., Smith, J.L., Alonso, E., Alford C., Cowart, L.A., Hannun, Y.A., Lyons, T. “Sphingolipids functions as downstream effectors of a fungal PAQR receptor”. Mol Pharmacol. 2008, 75(4):866-75.
Kupchak, B.R., Villa, N.Y., Kulemina, L., Lyons, T.J. “Dissecting the regulation of yeast genes by the osmotin receptor”. Biochem. Biophys. Res. Commun. 2008, 374(2): 210-213.
Smith, J.L., Kupchak, B.R., Garitaonandia, I., Maina, A.S., Regalla, L.M., Lyons, T.J. “Functional Expression of Human mPRα, mPRβ, mPRγ in Yeast and Identification of PAQR6 and PAQR9 as additional Membrane Progesterone Receptors”. Steroids. 2008 Oct;73(11):1160-73.
Kupchak, B.R., Garitaonandia, I., Villa, N.Y., Mullen, M.B., Weaver, M.G., Regalla, L.M., Kendall, E.A., Lyons, T.J. “Probing the Mechanism of FET3 Repression by Izh2p Overexpression”. Biochem. Biophys. Acta. 2007, 1773(7): 1124-1132.
Lyons, T. J., Villa, N. Y., Regalla, L.M., Kupchak, B. R., Vagstad. A. and Eide, D. J. “Metalloregulation of Yeast Membrane Steroid Receptor Homologues”. Proc. Natl. Acad. Sci. USA. 2004, 101(15): 5506-5511.
Foley, T.D., Armstrong, J.J., Kupchak, B.R., “Identification and H2O2 Sensitivity of the Major Constitutive MAPK Phosphatase from Rat Brain”. Biochem. Biophys. Res. Commun. 2004 Mar 12;315(3): 568-574.
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